generalized lipodystrophy造句

Leptin was approved in the United States in 2014 for use in congenital leptin deficiency and generalized lipodystrophy.
Human PTRF mutations may cause secondary deficiency of caveolins, resulting in generalized lipodystrophy in association with in muscular dystrophy.
Mutations in this gene have been associated with congenital generalized lipodystrophy, a disease characterized by a near absence of adipose tissue and severe insulin resistance.
In the US it is indicated as a treatment for complications of leptin deficiency, and for the diabetes and hypertriglyceridemia associated with congenital or acquired generalized lipodystrophy.
The minimal clinical criteria for the Keppen Lubinsky syndrome are as follows : normal growth parameters at birth, postnatal growth failure, peculiar facial appearance with skin tightly adherent to facial bones, generalized lipodystrophy and development delay.
It's difficult to find generalized lipodystrophy in a sentence. 用generalized lipodystrophy造句挺难的

It is has been approved in Japan for metabolic disorders including lipodystrophy and in the United States as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired generalized lipodystrophy.
Seipin mutations have been associated with congenital generalized lipodystrophy ( see below ), and mutations in an N-glycosylation motif links seipin to two other disorders, i . e . Silver syndrome and autosomal-dominant distal hereditary motor neuropathy type V.
On February 4, 2014, the U . S . FDA approved Myalept ( metreleptin ), an analog of human leptin, as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired generalized lipodystrophy.